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Andrographis paniculata (Burm.f.) Wall. ex Nees

Family Name: Acanthaceae
Synonyms: Justicia paniculata Burm.f.
Common Name: Bitterweed, King of Bitters, Creat, Green Chireta, Indian Echinachea, 穿心莲, 四方蓮

Andrographis paniculata, commonly known as the King of Bitters, is named for its intensely bitter tasting leaves. In traditional Chinese and Indian medicine, it is used to reduce fever, inflammation, blood sugar and high blood pressure. This common weed in the tropics and subtropics grows well in most soil types in semi-shade. Its white flowers have purple streaks and can self-pollinate.

Full Sun Moderate Water Coastal Plant Annual Herbaceous Plant

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Species Summary

Classifications and Characteristics

Plant Division Angiosperms (Flowering Seed Plants) (Dicotyledon)
Plant Growth Form Herbaceous Plant
Lifespan (in Singapore) Annual
Mode of Nutrition Autotrophic
Maximum Height 0.5 m

Biogeography

Native Distribution India, Sri Lanka
Native Habitat Terrestrial (Secondary Rainforest, Monsoon Forest, Coastal Forest, Disturbed Area / Open Ground)
Preferred Climate Zone Tropical, Sub-Tropical / Monsoonal

Description and Ethnobotany

Growth Form Annual herb with branched growth form up to 0.5 m tall.
Foliage Leaves (1.5-7 cm long, 1-2.5 cm wide) are ovate-lanceolate (intermediate between egg-shaped and lance-shaped), lanceolate or narrowly elliptic (narrow oval).
Stems Stems are hairless and 4-sided.
Flowers Two-lipped, tubular flowers (0.9-1.5 cm long) are white with the lower lip having purple dots. The outer surface of the tube is covered in glandular hairs (hairs with glands at the tip). Flowers are arranged in a secund raceme (a spike-like inflorescence composed of stalked flowers that are all pointing in a single direction). The racemes are arranged in branched clusters near the stem tip known as terminal panicles.
Fruits Dry, dehiscent fruit is known as a capsule (1.5-2 cm long, 0.3-0.4 cm wide). It has a flattened, oval shape. Each capsule contains about 12 wrinkled seeds (2 mm long, 1.5 mm wide).
Ethnobotanical Uses Edible Plant Parts (Edible Leaves)
Medicinal (

Scientific Evidence of Medicinal Properties

Pre-clinical and human clinical trials have shown that Bitterweed has anti-diabetic (Widjajakusuma et al., 2019), anti-inflammation (Burgos et al., 2009) and anti-microbial properties (Hu et al., 2017).

Pre-clinical trials on animals indicate it has analgesic (Ilmi et al., 2021), anti-cancer (Yue et al., 2019), antioxidant (Dandu & Inamdar 2009), cholesterol-lowering (Verma et al., 2013) and anti-malarial properties (Dua et al., 2004).

Traditional Medicinal Uses

Research supports the traditional use of Bitterweed to treat diabetes and upper respiratory ailments, such as bronchitis. Other traditional uses include treating insect and snake bites and preventing cardiovascular disease such as hypertension.

It is important to note that some therapeutic effects from traditional medicinal uses of plants are not currently supported or verified by scientific research. 

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Landscaping Features

Plant & Rootzone Preference - Tolerance Poor Infertile Soils, Well-Drained Soils, Fertile Loamy Soils, Saline Soils / Salt Spray, Easy to Grow
Landscape Uses General, Container Planting, Coastal
Thematic Landscaping Economic Garden
SGMP Treatment
Usage Hazard - Cons Toxic Upon Ingestion
Usage Hazard - Cons Remarks Plant has anti-fertility and abortive properties, may cause miscarriages if consumed in large quantities.

Fauna, Pollination and Dispersal

Seed or Spore Dispersal Abiotic (Explosive Dehiscence)

Plant Care and Propagation

Light Preference Full Sun
Water Preference Moderate Water
Plant Growth Rate Moderate
Propagation Method Seed, Stem Cutting

Foliar

Foliage Retention Evergreen
Mature Foliage Colour(s) Green
Mature Foliage Texture(s) Glossy / Shiny, Raised / Sunken Veins, Thin
Foliar Type Simple / Unifoliate
Foliar Arrangement Along Stem Opposite
Foliar Shape(s) Non-Palm Foliage (Lanceolate)
Foliar Venation Pinnate / Net
Foliar Margin Entire
Foliar Apex - Tip Acuminate
Foliar Base Rounded / Obtuse
Typical Foliar Area Microphyll ( 2.25cm2 - 20.25 cm2 )
Leaf Area Index (LAI) for Green Plot Ratio 4.5 (Shrub & Groundcover - Dicot)

Non - Foliar and Storage

Stem Type & Modification Herbaceous
Root Type Underground (Fibrous Root)

Floral (Angiosperm)

Flower & Plant Sexuality 1 Bisexual Flowers
Flower Colour(s) Purple, White
Flower Size - Remarks 1.2 cm
Inflorescence Type Panicle
Flowering Habit Polycarpic

Fruit, Seed and Spore

Mature Fruit Colour(s) - Angiosperms and Gymnosperms Brown
Fruit Classification Simple Fruit
Fruit Type 1 Dehiscent Dry Fruit
Fruit Type 2 Capsule
Mature Seed Texture(s) Ridged / Corrugated, Wrinkled
Seed Quantity Per Fruit Several (11-20)

References

References

Burgos, R.A., Hancke, J.L., Bertoglio, J.C., Aguirre, V., Arriagada, S., Calvo, M. & Caceres, D.D. (2009). Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clinical Rheumatology 28(8): 931-946.

Dandu, A.M. & Inamdar, N.M. (2009). Evaluation of beneficial effects of antioxidant properties of aqueous leaf extract of Andrographis paniculata in STZ-induced diabetes. Pakistan Journal of Pharmaceutical Sciences 22: 49-52.

Dua, V.K., Ojha, V.P., Roy, R., Joshi, B.C., Valecha, N., Devi, C.U., Bhatnagar, M.C., Sharma, V.P. & Subbarao, S.K. (2004). Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata. Journal of Ethnopharmacology 95(2-3): 247-251.

Hu, X.Y., Wu, R.H., Logue, M., Blondel, C., Lai, L.Y.W., Stuart, B., Flower, A., Fei, Y.T., Moore, M., Shepherd, J., Liu, J.P. & Lewith, G. (2017). Andrographis paniculata (Chuan Xin Lian) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis. PLoS ONE 12(8): e0181780.

Ilmi, H., Pamungkas I.R., Tumewu, L., Hafid, A.F. & Widyawaruyanti, A. (2021). Analgesic and antipyretic activities of ethyl acetate fraction tablet of Andrographis paniculata in animal models. Evidence-Based Complementary and Alternative Medicine Article ID 8848797.

Verma, V.K., Sarwa, K.K. & Zaman, M.K. (2013).  Antihyperglycemic activity of Swertia chirayita and Andrographis paniculata plant extracts in streptozotocin-induced diabetic rats. International Journal of Pharmacy and Pharmaceutical Sciences 5(3): 305-311. 

Widjajakusuma, E.C., Jonosewojo, A., Hendriata, L., Wijaya, S., Ferawati, Surjadhana, A., Sastrowardoyo, W., Monita, N., Muna, N.M., Fajarwati, R.P., Ervina, M., Esar, S.Y., Soegianto, L., Lang, T. & Heriyanti, C. (2019). Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm.f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes. Phytomedicine 55: 137-147.

Yue, G.G.L., Li, L., Lee, J.K.M., Kwok, H.F., Wong, E.C.W., Li, M., Fung, K.P., Yu, J., Chan, A.W.H., Chiu, P.W.Y. & Lau, C.B.S. (2019). Multiple modulatory activities of Andrographis paniculata on immune responses and xenograft growth in esophageal cancer preclinical models. Phytomedicine 60: Article 152886. 

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Master ID 369
Species ID 1665
Flora Disclaimer The information in this website has been compiled from reliable sources, such as reference works on medicinal plants. It is not a substitute for medical advice or treatment and NParks does not purport to provide any medical advice. Readers should always consult his/her physician before using or consuming a plant for medicinal purposes.
Species record last updated on: 04 October 2022.
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